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International Journal of Poultry Science

.: Home > International Journal of Poultry Science > 2009 > Volume 8 Number 8 > H.A. Arab1, S.H. Mardjanmehr2, A. Shahbazfar2, A. Rassouli1, M. Abdollahi3 and O. Nekouie4

Toxicopathologic Effects of Artemisinin in Broiler Chickens Following a Single Oral Dose: An LD Study

H.A. Arab1, S.H. Mardjanmehr2, A. Shahbazfar2, A. Rassouli1, M. Abdollahi3 and O. Nekouie4
1Department of Pharmacology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran 2Department of Pathology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran 3Department of Toxicology and Pharmacology, School of Pharmacy, Tehran University of Medical Science, Tehran, Iran 4Department of Food Hygiene and Epidemiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
Abstract :

The present study aimed to find LD of artemisinin and to characterize the single dose toxicity of 50
the drug following oral exposure. 49 day-old Ross broilers divided into 7 groups; one control, one drug
vehicle and five treatment groups. The treatment groups received artemisinin alcoholic solution at doses of
10, 50, 250, 1250 and 2500 mg/kg on day 30 by a crop tube. The control and drug vehicle groups received
normal saline and ethyl alcohol, respectively. In the period of study just in 1250 and 2500 mg/kg groups there were a few transient neurological signs like depression and unconsciousness. These signs were also observed in drug vehicle group. None of the birds died, so they were euthanised on day 40. In microscopic examination, only in treatment groups a slight degeneration in liver and kidney as intracytoplasmic eosinophilic inclusions, hepatocellular swelling and bile retention in liver were evident. In brain central chromatolysis, scattered neuronal necrosis, spongy change and focal axonal swelling were observed. It is concluded that artemisinin has a good margin of safety in poultry but in very high doses it may cause some adverse effects.

Keywords :
Artemisinin, broilers, toxicopathology, single dose, neurotoxicity

Date Deposited : 06 Jul 2011 11:01

Last Modified : 06 Jul 2011 11:01

Official URL: http://www.pjbs.org/ijps/ijps.htm

Volume 8, Number 8, - 2009 , ISSN 1682-8356

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