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International Journal of Poultry Science

.: Home > International Journal of Poultry Science > 2009 > Volume 8 Number 9 > Gabriela V. G-Verduzco1, Guillermo Tellez2, Michael H. Kogut3, Armando Isibasi4 and Vianney Ortiz-Navarrete5

Presence of Interferon-Gamma and IL-2 in Supernatants of Salmonella enteritidis-Immune Lymphokines

Gabriela V. G-Verduzco1, Guillermo Tellez2, Michael H. Kogut3, Armando Isibasi4 and Vianney Ortiz-Navarrete5
1Departamento de Produccion Animal, Aves, FMVZ, UNAM, CD. Universitaria, Mexico City, Mexico D.F. 04510 2Department of Poultry Science, University of Arkansas, Fayetteville, AR 72701, USA 3Southern Plains Agricultural Research Center, USDA-ARS, 2881, F and B Road, College Station, TX 77845, USA 4Unidad de Investigacion Medica en Inmunoquimica del Hospital de Especialidades del Centro Medico Nacional del IMSS, Mexico City, Mexico, D.F. 03020 5Departamento de Biomedicina Molecular del Centro de Investigacion y de Estudios Avanzados del IPN (CINVESTAV), Mexico City, Mexico, D.F. 07360
Abstract :

Investigations in our laboratories have indicated that an increased resistance to Salmonella enteritidis SE organ infectivity in chickens was conferred by the immunoprophylactic administration of SEimmune
lymphokines (SE-ILK). Resistance has been associated with an enhanced heterophilic accumulation within 4 h of ILK injection. Further studies demonstrated that CxCLi2 is produced locally by the host in response to both the SE infection and the SE-ILK suggesting that IL-8 is a major chemotactic factor produced by the host, which aids in mediating the SE-ILK induced recruitment of heterophils to the site of
SE invasion. In the present study, two bio-assays confirmed the presence of IFN and IL-2 functions in  SE-ILK that may also participate in the establishment of the reported protection against Salmonella infections. The IL-2 and IFN effects detected in this work suggest that bird’s immune response develops similarly to that of mammals, with some features corresponding to the species.

Keywords :
Salmonella, cytokines, inflammation, chickens

Date Deposited : 06 Jul 2011 11:17

Last Modified : 06 Jul 2011 11:17

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Volume 8, Number 9, - 2009 , ISSN 1682-8356

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