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International Journal of Poultry Science

.: Home > International Journal of Poultry Science > 2008 > Volume 7 Number 2 > Tariq M. Hantash1, Ehab A. Abu-Basha2, Dergham A. Roussan1 and Alaeldein M. Abudabos3

Pharmacokinetics and Bioequivalence of Doxycycline (Providox® and Doxyvet 0-50 S®) Oral Powder Formulations in Chickens

Tariq M. Hantash1, Ehab A. Abu-Basha2, Dergham A. Roussan1 and Alaeldein M. Abudabos3
1Provimi - Jordan - P.O. Box: 499, Amman 11118, Jordan 2Department of Veterinary Basic Medical Sciences, Faculty of Veterinary Medicine, Jordan University of Science and Technology, Irbid, Jordan 3Department of Animal Production, Faculty of Agriculture, Mu’tah University, Kerak, Jordan 61710
Abstract :

A bioequivalence and pharmacokinetics profiles of two doxycycline powder formulations (Providox® and Doxyvet 0-50 S®) were compared in 24 healthy chickens following administration of a single oral dose
(20 mg/kg bw). Serial blood samples were drawn at 10 points after administration to determine doxycycline
concentrations in chicken plasma by HPLC/UV. the pharmacokinetics parameters; area under plasma
concentration-time curve (AUC ), maximum plasma concentration (C ) were determined for both 0-24 max
formulations. The average means of AUC and C for Providox and Doxyvet 0-50 S were very close 0–24 max
® ® (62.32 ± 3.34 and 57.55 ± 4.66 ىg.h/ml and 5.36 ± 0.26 and 5.08 ± 0.25 ىg/ml, respectively) with no
significant differences based on ANOVA. The 90% confidence intervals of the parameters AUC and C 0–24 max between two formulations were within the range 80 to 125 % of bioequivalence according to US FDA
regulation. The relative bioavailability of Providox® compared to Doxyvet 0-50 S® was 108.24%. Therefore, the Providox® and Doxyvet 0 - 50 S® were considered to be bioequivalent.

Keywords :
Bioavailability, bioequivalence, chicken, doxycycline and pharmacokinetics

Date Deposited : 07 Jul 2011 13:52

Last Modified : 07 Jul 2011 13:52

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Volume 7, Number 2, - 2008 , ISSN 1682-8356

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