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International Journal of Poultry Science

.: Home > International Journal of Poultry Science > 2007 > Volume 6 Number 1 > P. Krishnamoorthy1, S. Vairamuthu2, C. Balachandran2 and B. Muralimanohar3

Pathology of Lymphoid Organs in Chlorpyriphos and T-2 Toxin Fed Broiler Chicken

P. Krishnamoorthy1, S. Vairamuthu2, C. Balachandran2 and B. Muralimanohar3
1Postgraduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600 113, Tamilnadu, India 2Department of Veterinary Pathology, Madras Veterinary College, Chennai-600 007, Tamilnadu, India 3Centre for Animal Health Studies, Tamilnadu Veterinary and Animal Sciences University, Madhavaram Milk Colony, Chennai-600051, Tamilnadu, India
Abstract :

Forty-eight, newly hatched, unsexed broiler chicks were fed diets containing 45 mg/kg chlorpyriphos, an organophosphorus compound and 0.5 mg/kg T-2, a mycotoxin singly and in combination for 28 days from day of hatch to study the pathology of lymphoid organs. A system for scoring microscopic lesions was developed in bursa of Fabricius, caecal tonsil and spleen. Lesion scores for bursa ranged from 0 for normal, 2 for chlorpyriphos toxicosis and 4 for T-2 and chlorpyriphos+T-2 fed birds on 14th and 28th day
of study. Less severe lesions occurred in caecal tonsils with score 1 in all the toxin fed birds. The lesion
score for spleen ranged from 0 for normal to 3 for severely affected spleen in combined toxin fed birds on
14th and 28th day of trial. In T-2 fed group, thymus showed mild medullary lymphocytolysis on 14th day of
trial. Harderian gland of all the toxin fed birds showed depletion of plasma cells and necrosis of the gland
on 14th and 28th day of age. This lesion scoring system was useful in determining the severity of these two toxins singly and in combination on lymphoid organs in different age group of broilers. The present study revealed the individual and combined toxic effects of these toxins on the lymphoid organs and affecting the health status in broiler chicken.

Keywords :
Broiler chicken, chlorpyriphos, T-2 toxin, lymphoid organs

Date Deposited : 14 Jul 2011 10:49

Last Modified : 14 Jul 2011 10:49

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Volume 6, Number 1, - 2007 , ISSN 1682-8356

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