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.: Home > Nature and Science > 2011 > Volume 9 Number 2 > Kamel. A. M. Eid,1 Heba. F. Salem,2 Amina A. F. Zikry,1 Ali .F. M. El-Sayed,3 Mohammed A. Sharaf1,4

Antifungal Effects of Colloidally Stabilized Gold Nanoparticles: Screening by Microplate Assay

Kamel. A. M. Eid,1 Heba. F. Salem,2 Amina A. F. Zikry,1 Ali .F. M. El-Sayed,3 Mohammed A. Sharaf1,4
1Department of Chemistry, Helwan University, Ain Helwan, Helwan 11795, EGYPT 2Department of Pharmaceutics, Faculty of Pharmacy, Beni Souef University, Beni Souef, EGYPT 3Applied Research Sector, Egy-Vac/ VACSERA, Giza, 22311, EGYPT 4Currently: Department of Chemistry, The American University in Cairo, New Cairo, Helwan 11835, EGYPT sharafma@aucegypt.edu
Abstract :

Collidally stabilized gold nanoparticles NPs having sizes in the range of 3-20 nm have been prepared by
citrate chemical reduction methods. The gold nanoparticles were characterized employing transmission electron microscopy TEM. The in vitro release kinetics and associated antifungal effects were investigated for Pencillium. Micro plate reader analyses were utilized for monitoring the antifungal effects. The results provided strong evidence that could warrant the consideration of gold nanoparticles as antifungal material. Such treatment could circumvent the side and passive immune effects of other antifungal material. Also, the nanoparticles thus prepared have the potential and ability of targeting specific sites. [Kamel. A. M. Eid, Heba. F. Salem, Amina A. F. Zikry, Ali .F. M. El-Sayed, Mohammed A. Sharaf. Antifungal Effects of Colloidally Stabilized Gold Nanoparticles: Screening by Microplate Assay. Nature and Science 2011;9(2):29-33]. (ISSN: 1545-0740). http://www.sciencepub.net.

Keywords :
gold nanoparticles; colloidally stabilized; antifungal; microplate assay; release kinetics

Date Deposited : 12 Jan 2011 14:14

Last Modified : 12 Jan 2011 14:14

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Volume 9, Number 2, February 2011 , ISSN 1545-0740

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