UMM Logo

Universitas Muhammadiyah Malang


Free Download Journals Directory


International Journal of Medical Sciences

.: Home > International Journal of Medical Sciences > 2009 > Volume 6 Number 2 > Wolfram Windisch, Moritz Haenel, Jan H Storre and Michael Dreher

High-intensity non-invasive positive pressure ventilation for stable hypercapnic COPD

Wolfram Windisch, Moritz Haenel, Jan H Storre and Michael Dreher
Department of Pneumology, University Hospital Freiburg, Germany
Abstract :

Background: The objective of the present analysis is to describe the outcomes of high-intensity non-invasive positive pressure ventilation (NPPV) aimed at maximally decreasing PaCO2 as an alternative to conventional NPPV with lower ventilator settings in stable hypercapnic COPD patients. Methods: Physiological parameters, exacerbation rates and long-term survival were assessed in 73 COPD patients (mean FEV1 30پ}12 %predicted) who were established on high-intensity NPPV due to chronic hypercapnic respiratory failure between March 1997 and May 2006. Results: Controlled NPPV with breathing frequencies of 21پ}3 breath/min and mean inspiratory/ expiratory positive airway pressures of 28پ}5/5پ}1 cmH2O led to significant improvements in blood gases, lung function and hematocrit after two months. Only sixteen patients (22%) required hospitalisation due to exacerbation during the first year, with anaemia increasing the risk for exacerbation. Two- and five-year survival rates of all patients were 82% and 58%, respectively. The five year survival rate was 32% and 83% in patients with low (.39%) and high (.55%) hematocrit, respectively. Conclusion: High-intensity NPPV improves blood gases, lung function and hematocrit, and is also associated with low exacerbation rates and a favourable long-term outcome. The
current report strongly emphasises the need for randomised controlled trials evaluating the role of high-intensity NPPV in stable hypercapnic COPD patients.

Keywords :
COPD, exacerbation, hematocrit, non-invasive ventilation, survival

Date Deposited : 27 Jul 2011 13:06

Last Modified : 27 Jul 2011 13:06

Official URL: http://www.medsci.org/archive

Volume 6, Number 2, - 2009 , ISSN 1449-1907

Download:
Full Text Original
Abstract : pdf doc
Home | Peta Situs | Admissions | Student Research | E-Journal
Universitas Muhammadiyah Malang © 2011
Developed by Infokom UMM
Last Update : 13 December 2016 20:46Kumpulan file jurnal