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International Journal of Medical Sciences
.: Home > International Journal of Medical Sciences > 2009 > Volume 6 Number 6 > David C. Crowley1, Francis C. Lau2, Prachi Sharma1, Malkanthi Evans1, Najla Guthrie1, Manashi Bagchi2, Debasis Bagchi2,3, Dipak K. Dey4, Siba P. Raychaudhuri 5,6
Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trialDavid C. Crowley1, Francis C. Lau2, Prachi Sharma1, Malkanthi Evans1, Najla Guthrie1, Manashi Bagchi2, Debasis Bagchi2,3, Dipak K. Dey4, Siba P. Raychaudhuri 5,6
1. KGK Synergize Incorporated, London, ON, Canada
2. Department of Research and Development, InterHealth Research Center, Benicia, CA, USA
3. Department of Pharmacology and Pharmaceutical Sciences, University of Houston College of Pharmacy, Houston, TX,
USA
4. Department of Statistics, University of Connecticut, Storrs, CT, USA
5. Department of Medicine, Division of Rheumatology, Allergy and Immunology, School of Medicine, University of
California Davis, Davis, CA, USA
6. VA Medical Center Sacramento, Hospital Way, Mather, CA, USA
Abstract :
Previous studies have shown that undenatured type II collagen (UC-II) is effective in the treatment of rheumatoid arthritis, and preliminary human and animal trials have shown it to be effective in treating osteoarthritis (OA). The present clinical trial evaluated the safety and efficacy of UC-II as compared to a combination of glucosamine and chondroitin (G+C) in the treatment of OA of the knee. The results indicate that UC-II treatment was more efficacious resulting in a significant reduction in all assessments from the baseline at 90 days; whereas, this effect was not observed in G+C treatment group. Specifically, although both treatments reduced the Western Ontario McMaster Osteoarthritis Index (WOMAC) score, treatment Keywords :
undenatured type II collagen, osteoarthritis, glucosamine, chondroitin, WOMAC, visual analog scale, Lequesne’s Functional Index
Date Deposited : 28 Jul 2011 10:14 Last Modified : 28 Jul 2011 10:14 Volume 6, Number 6, - 2009 , ISSN 1449-1907
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