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International Journal of Medical Sciences

.: Home > International Journal of Medical Sciences > 2008 > Volume 5 Number 5 > Matthew Kaufman1, Bhoomi Mehrotra1, Sewanti Limaye1, Sherrie White2, Alexander Fuchs1, Yehuda Lebowicz1, Sandy Nissel-Horowitz1, Adrienne Thomas1

EGFR Expression in Gallbladder Carcinoma in North America

Matthew Kaufman1, Bhoomi Mehrotra1, Sewanti Limaye1, Sherrie White2, Alexander Fuchs1, Yehuda Lebowicz1, Sandy Nissel-Horowitz1, Adrienne Thomas1
1. Long Island Jewish Medical Center, New Hyde Park, NY 11040, USA 2. Hartford Hospital, Hartford, CT, USA
Abstract :

BACKGROUND: Increased epidermal growth factor receptor (EGF receptor) expression has been noted in various cancers and has become a useful target for therapeutic interventions. Small studies from Asia and Australia have demonstrated EGFR over-expression in gallbladder cancer. We sought to evaluate the expression of EGFR in a series of 16 gallbladder cancer patients from North America.
METHODS: Using tumor registry data, we identified 16 patients diagnosed with gall bladder carcinoma at our medical center between the years of 1998 and 2005. We performed a retrospective review of these patients’ charts, obtained cell blocks from pathology archives and stained for EGFR and Her2/neu. RESULTS: Fifteen of sixteen patients were noted to over-express EGFR. Three were determined 1+, nine were 2+ and three were 3+. Eight patients had poorly differentiated adenocarcinoma, six had moderately differentiated and two had well-differentiated tumors. In this small series, there was a trend toward shorter survival and more poorly differentiated tumors in patients with greater intensity of EGFR expression. One patient was EGFR negative but 3+ for erb-2/Her 2-neu expression. No patient co-expressed EGFR and Her-2-neu. Median survival of patients in this series was 17 months. CONCLUSION: In view of our observations confirming the over-expression of EGFR in our patient population in North America, and the recent success of EGFR targeted therapies in other solid tumors that over-express EGFR, it may now be appropriate to evaluate agents targeting this pathway either as single agents or in combination
with standard chemotherapy.

Keywords :
gallbladder cancer, endothelial growth factor receptor (EGFR), differentiation, survival, her-2-neu

Date Deposited : 28 Jul 2011 11:18

Last Modified : 28 Jul 2011 11:18

Official URL: http://www.medsci.org/archive

Volume 5, Number 5, - 2008 , ISSN 1449-1907

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