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International Journal of Medical Sciences

.: Home > International Journal of Medical Sciences > 2008 > Volume 5 Number 5 > Daniel Chesik, Nadine Wilczak and Jacques De Keyser

IGF-1 regulates cAMP levels in astrocytes through a â2-adrenergic receptor- dependant mechanism

Daniel Chesik, Nadine Wilczak and Jacques De Keyser
Abstract :

We have recently demonstrated that neonatal astrocytes derived from mice lacking beta-2 adrenergic  eceptors (â2AR) possess higher proliferation rates, as compared to wild-type cells, an attribute that was shown to involve insulin-like growth factor (IGF) signaling. In the present study, we demonstrate that basal cAMP levels in â2AR knockout astrocytes were significantly lower than in wild type cells. Furthermore, treatment with IGF-1 reduced intracellular cAMP levels in wild type astrocytes, yet had no effects on cAMP levels in â2AR deficient astrocytes. Our data suggests that IGF-1 treatment influences cAMP production through a â2AR-dependant mechanism in astrocytes. A deficit of â2AR on astrocytes, as previously reported in multiple sclerosis, may influence cell proliferation, an action which could have implications in processes involved in astrogliosis.

Keywords :
beta adrenergic receptors, insulin-like growth factor, cyclic adenosine monophosphate, astrocytes, multiple sclerosis

Date Deposited : 28 Jul 2011 11:20

Last Modified : 28 Jul 2011 11:20

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Volume 5, Number 5, - 2008 , ISSN 1449-1907

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