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.: Home > International Journal of Medical Sciences > 2006 > Volume 3 Number 2 > Thomas D. Schiano, and Paul Martin

Management of HCV Infection and Liver Transplantation

Thomas D. Schiano, and Paul Martin
Adult Liver Transplantation, Recanati/Miller Transplantation Institute, Division of Liver Diseases, Department of Medicine, The Mount Sinai School of Medicine, New York, NY, USA
Abstract :

A major challenge facing liver transplant recipients and their physicians is recurrence of hepatitis C virus infection following otherwise technically successful liver transplantation. Recurrent infection leads to diminished graft and patient survival. Although a number or predictors of severe recurrence have been identified, no definitive strategy has been developed to prevent recurrence. Generally the tempo of hepatitis C recurrence is gauged by serial liver biopsies with the decision to intervene with antiviral therapy based on local philosophy and expertise. Treating hepatitis C in this population has a number of major challenges including diminished patient tolerance for  side-effects as well as managing the patient’s immunesuppression. However sustained viral responses are possible with the potential to reduce the impact of recurrent hepatitis on the graft. However recurrent hepatitis C virus infection will remain the most frequent form of recurrent disease in liver transplant programs for the foreseeable future.

Keywords :
recurrent hepatitis C, liver transplantation, antiviral therapy

Date Deposited : 29 Jul 2011 13:39

Last Modified : 29 Jul 2011 13:39

Official URL: http://www.medsci.org/archive

Volume 3, Number 2, - 2006 , ISSN 1449-1907

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