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.: Home > International Journal of Medical Sciences > 2006 > Volume 3 Number 2 > Volker Brass1, Darius Moradpour2 and Hubert E. Blum1

Molecular Virology of Hepatitis C Virus (HCV): 2006 Update

Volker Brass1, Darius Moradpour2 and Hubert E. Blum1
1. Department of Medicine II, University of Freiburg, D-79106 Freiburg, Germany 2. Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, CH-1011 Lausanne, Switzerland
Abstract :

Fascinating progress in the understanding of the molecular biology of hepatitis C virus (HCV) was achieved recently. The replicon system revolutionized the investigation of HCV RNA replication and facilitated drug discovery. Novel systems for functional analyses of the HCV glycoproteins allowed the validation of HCV receptor candidates and the investigation of cell entry mechanisms. Most recently, recombinant infectious HCV could be produced in cell culture, rendering all steps of the viral life cycle, including entry and release of viral particles, amenable to systematic analysis.
In this review, we summarize recent advances and discuss future research directions.

Keywords :
helicase, hepatitis C virus, protease, polymerase, replicon

Date Deposited : 29 Jul 2011 13:40

Last Modified : 29 Jul 2011 13:40

Official URL: http://www.medsci.org/archive

Volume 3, Number 2, - 2006 , ISSN 1449-1907

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