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.: Home > International Journal of Medical Sciences > 2006 > Volume 3 Number 2 > John Hoefs 1 and Vikramjit S. Aulakh 2

Treatment of Chronic HCV Infection in Special Populations

John Hoefs 1 and Vikramjit S. Aulakh 2
1. Division of Gastroenterology and Hepatology, H.H. Chao Comprehensive Digestive Disease Center UCI Medical Center, Orange, CA, USA. 2. Mercy Hospital and Medical Center, 2525 S Michigan Ave, Chicago, Illinois, USA.
Abstract :

The mainstay of treatment of chronic hepatitis C is pegylated interferon combined with ribavirin and more than 50% of naïve patients will have viral cure with either 6 months (genotypes 2 and 3) or 12 months (genotypes 1,4, and 6) with the initial treatment. However, populations have been defined that respond less well to routine treatment including African Americans, immune  suppressed populations, obese patients and cirrhotic patients. These types of patients are enriched
in groups of patients who are non-responders to treatment. This article discusses viral kinetics that may impact treatment response, strategies to maximize treatment effectiveness in these populations and the treatment of nonresponders in general. Early viral kinetics can be used to define response or non-response and these results can be used to modify subsequent treatment length and dose.

Keywords :
HCV, treatment HCV, non-responder, cirrhosis, African American, fatty liver

Date Deposited : 29 Jul 2011 13:42

Last Modified : 29 Jul 2011 13:42

Official URL: http://www.medsci.org/archive

Volume 3, Number 2, - 2006 , ISSN 1449-1907

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