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International Journal of Medical Sciences

.: Home > International Journal of Medical Sciences > 2006 > Volume 3 Number 3 > Jens Aberle, Inga Hopfer, Frank Ulrich Beil, Udo Seedorf

Association of the T+294C polymorphism in PPAR ن with low HDL cholesterol and coronary heart disease risk in women

Jens Aberle, Inga Hopfer, Frank Ulrich Beil, Udo Seedorf
Zentrum für Innere Medizin, Universitنtsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany
Abstract :

Background: The +T294C polymorphism in PPARن represents a functional SNP affecting transcriptional activity of the PPARن gene. To address whether this polymorphism is associated with the risk for coronary heart disease and/or plasma lipid levels in women, we studied a group of 967 female patients with hyperlipidaemia in the presence (n=453) or absence (n=514) of coronary heart disease. Methods: 967 female patients with or without coronary heart disease were genotyped using mutagenically separated polymerase chain reaction (MS-PCR). Statistical analysis was performed according to genotype with parameters of lipid metabolism as dependant variables. Results: A highly significant association between the rare C allele and lower plasma HDL concentrations was found in female subjects. The effect remained significant after correcting for multiparametric testing according to Bonferoni and was seen only in subjects with a BMI below the median. Moreover, a significant association of the C-allele with coronary heart disease and BMI was obtained. Regarding the entire group, trends towards higher VLDL and LDL levels were observed. Conclusions: Our data show for the first time that the PPARن +T294C polymorphism is associated with lipid levels and coronary heart disease in women. However, the molecular mechanism of action remains to be elucidated.

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Date Deposited : 30 Jul 2011 11:06

Last Modified : 30 Jul 2011 11:06

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Volume 3, Number 3, - 2006 , ISSN 1449-1907

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