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International Journal of Medical Sciences

Gene Therapy: The Potential Applicability of Gene Transfer Technology to the Human Germline

Kevin R. Smith
School of Contemporary Sciences, University of Abertay, Dundee, DD1 1HG, United Kingdom
Abstract :

The theoretical possibility of applying gene transfer methodologies to the human germline is explored. Transgenic methods for genetically manipulating embryos may in principle be applied to humans. In particular, microinjection of retroviral vector appears to hold the greatest promise, with transgenic primates already obtained from this approach. Sperm-mediated gene transfer offers potentially the easiest route to the human germline, however the requisite methodology is presently underdeveloped. Nuclear transfer (cloning) offers an alternative approach to germline genetic modification, however there are major health concerns associated with current nuclear transfer methods. It is concluded that human germline gene therapy remains for all practical
purposes a future possibility that must await significant and important advances in gene transfer technology.

Keywords :
gene targeting; gene therapy; genetic modification; pronuclear microinjection; sperm-mediated gene transfer

Date Deposited : 04 Aug 2011 10:11

Last Modified : 04 Aug 2011 10:11

Official URL: http://www.medsci.org/archive

Volume 1, Number 2, - 2004 , ISSN 1449-1907

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