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.: Home > International Journal of Medical Sciences > 2004 > Volume 1 Number 2 > Manash K. Paul and Anup K. Mukhopadhyay

Tyrosine kinase – Role and significance in Cancer

Manash K. Paul and Anup K. Mukhopadhyay
Department of Biotechnology, National Institute of Pharmaceutical Education and Research, Sector-67, S.A.S Nagar, Mohali, Punjab, India-160062
Abstract :

Tyrosine kinases are important mediators of the signaling cascade, determining key roles in diverse biological processes like growth, differentiation, metabolism and apoptosis in response to external and internal stimuli. Recent advances have implicated the role of tyrosine kinases in the pathophysiology of cancer. Though their activity is tightly regulated in normal cells, they may acquire transforming functions due to mutation(s), overexpression and autocrine paracrine  stimulation, leading to malignancy. Constitutive oncogenic activation in cancer cells can be  blocked by selective tyrosine kinase inhibitors and thus considered as a promising approach for
innovative genome based therapeutics. The modes of oncogenic activation and the different approaches for tyrosine kinase inhibition, like small molecule inhibitors, monoclonal antibodies, heat shock proteins, immunoconjugates, antisense and peptide drugs are reviewed in light of the
important molecules. As angiogenesis is a major event in cancer growth and proliferation, tyrosine kinase inhibitors as a target for anti-angiogenesis can be aptly applied as a new mode of cancer therapy. The review concludes with a discussion on the application of modern techniques and knowledge of the kinome as means to gear up the tyrosine kinase drug discovery process.

Keywords :
Tyrosine kinase; Cancer; Oncogenic activation; Inhibitor; Drug discovery

Date Deposited : 04 Aug 2011 10:12

Last Modified : 04 Aug 2011 10:12

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Volume 1, Number 2, - 2004 , ISSN 1449-1907

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