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International Journal of Medical Sciences

.: Home > International Journal of Medical Sciences > 2004 > Volume 1 Number 3 > Mohamed El-Sammak1, Mona Kandil 1, Safaa El-Hifni1, Randa Hosni2, Mahmoud Ragab1

Elevated plasma homocysteine is positively associated with age independent of C677T mutation of the methylenetetrahydrofolate reductase gene in selected Egyptian subjects

Mohamed El-Sammak1, Mona Kandil 1, Safaa El-Hifni1, Randa Hosni2, Mahmoud Ragab1
1 Departments of Chemical Pathology, Medical Research Institute Hospital, Alexandria University, Egypt. 2 Internal Medicine (Cardiology Unit), Medical Research Institute Hospital, Alexandria University, Egypt.
Abstract :

This study aimed to evaluate the plasma homocysteine (tHcy) and folate levels as well as the methylenetetrahydrofolate reductase (MTHFR) C677T mutation in Egyptian subjects. Fasting total homocysteine (tHcy) and the (MTHFR) C677T mutation were evaluated in 50 healthy young control males (age 35-50 years, Gp1), 50 elderly males age ranged between 50-75 years without any cardiovascular diseases (Gp2) and 50 age matched elderly male patients (Gp3) with myocardial infarction. There was a significant elevation of plasma tHcy in the patients group and Gp2 compared to the young control group (Gp1). The total plasma homocysteine (tHcy) in the control group, Gp2 and the patients group were 17.99 ± 9.76, 39.9 ± 20.06 and
43.8 ± 13.13 ىmol/L respectively. The frequency of the TT genotype was 12% in the patient group compared with 8 % in the young healthy controls and elderly subjects (Gp2). The CT genotype constituted 36%, 48% and 44% in the control group, Gp2 and the patients group respectively. There was no significant difference in the occurrence of the TT genotype between the studied groups. Plasma tHcy correlated positively with age, total cholesterol, urea, creatinine, glucose levels and carotid intimal thickness (CIT). Conclusion: The MTHFR mutation does not seem to be associated with either high tHcy or the occurrence of cardiovascular diseases in the studied patients. However, elevated plasma tHcy level positively correlates with age in the studied subjects.

Keywords :
Homocysteine, MTHFR, coronary heart disease

Date Deposited : 04 Aug 2011 10:36

Last Modified : 04 Aug 2011 10:36

Official URL: http://www.medsci.org/archive

Volume 1, Number 3, - 2004 , ISSN 1449-1907

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