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Animal Science Papers and Reports

.: Home > Animal Science Papers and Reports > 2009 > Volume 27 Number 2 > El؟bieta Wirth-Dziêcio³owska1,3,*, Jadwiga Karaszewska1, Tomasz Sadowski2, Kazimiera Pyœniak1, Marta Gajewska1

Selected blood serum biochemical indicators in twelve inbred strains of laboratory mice

El؟bieta Wirth-Dziêcio³owska1,3,*, Jadwiga Karaszewska1, Tomasz Sadowski2, Kazimiera Pyœniak1, Marta Gajewska1
1 Department of Genetics and Laboratory Animal Breeding, The Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology in Warsaw, Roentgena 5, 02-781 Warsaw, Poland 2 Department of Clinical Chemistry, The Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology in Warsaw, Roentgena 5, 02-781 Warsaw, Poland 3 Department of Genetics and Animal Breeding, Warsaw Agricultural University, Ciszewskiego 8, 02-786 Warsaw, Poland
Abstract :

A total of 215 animals of twelve inbred strains of mice (A.CA/W, AKR/W, BALB/cW, BN/aW,
C57BL/6W, C57Bl/10W, CBA/W, CBAT6/W, C3H/W, DBA/2W, 129Sl/SvW and HLB/219J) bred
at the Cancer Centre and Institute of Oncology, Warsaw (Oncology Centre), were characterized in
terms of five blood serum biochemical indicators related to their health, reproduction and genetic
background. Glucose, total protein, creatinine, triglycerides (triacylglycerols) and total cholesterol
were determined in mice aged four months. Significant interstrain differences were found among
nearly all parameters considered, with the exception of total protein. The level of triglycerides
showed wide interstrain differences and revealed a similar variation trend as the total cholesterol.
For cholesterol and triglycerides, significant differences between sexes for the majority of strains
were found. The results obtained may be important in the selection of experimental animals,
for analysis of changes associated with various diseases, and for the explanation of their genetic
background.

Keywords :
biochemical blood indicators / blood / inbred strains / mice

Date Deposited : 04 Aug 2011 13:27

Last Modified : 04 Aug 2011 13:27

Official URL: http://www.ighz.edu.pl/

Volume 27, Number 2, - 2009

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