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.: Home > Animal Science Papers and Reports > 2009 > Volume 27 Number 4 > Ewa Ochwanowska1*, Bo؟ena Witek1, Adam Ko³¹taj2

The effect of intraperitoneally administered glucagon on the lysosomal enzyme activity in the liver of the mice

Ewa Ochwanowska1*, Bo؟ena Witek1, Adam Ko³¹taj2
1 Department of Animal Physiology, The Jan Kochanowski University of Kielce, Œwiêtokrzyska 15, 25-406 Kielce, Poland 2 Polish Academy of Sciences Institute of Genetics and Animal Breeding, Jastrzêbiec, 05-552 Wَlka Kosowska, Poland
Abstract :

The experiment was carried out on 20 Swiss male mice divided into experimental (E, n=10) and
control (C, n=10) group. E mice were intraperitoneally injected with glucagon (15 ىg/kg b.w.) twice
daily for eight days, while mice C with 250 ىl 0.9% NaCl/mouse (to exclude the injection effect only). In the lysosomal fraction of the liver the activities of acid phosphatase, â-N-acetyl-hexosaminidase, â-glucuronidase, â-glucosidase, lysosomal arylesterase, lysosomal lipase, leucine aminopeptidase and alanine aminopeptidase were determined. Glucagon caused an increase of activity of all studied enzymes except â-glucuronidase and â-glucosidase, where reduced activities were observed.

Keywords :
adaptation / glucagon / glucose / lysosomal enzymes / mice

Date Deposited : 06 Aug 2011 10:42

Last Modified : 06 Aug 2011 10:42

Official URL: http://www.ighz.edu.pl/

Volume 27, Number 4, - 2009

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