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.: Home > Animal Science Papers and Reports > 2007 > Volume 25 Number 4 > Tadeusz Zagulski, Pawe³ Lipiٌski, Lech Zwierzchowski, Kazimierz Jaszczak, Bogdan Sadowski, Mariusz Sacharczuk*

Stimulating effect of bovine lactoferrin (bLF) on the level of lipopolisaccharide-binding protein (LBP) during experimental diabetes in mice

Tadeusz Zagulski, Pawe³ Lipiٌski, Lech Zwierzchowski, Kazimierz Jaszczak, Bogdan Sadowski, Mariusz Sacharczuk*
Polish Academy of Sciences Institute of Genetics and Animal Breeding, Jastrzêbiec, 05-552 Wَlka Kosowska, Poland
Abstract :

Reduced inflammatory responses are frequently associated with diabetes mellitus. In order to
investigate the influence of diabetes mellitus on the activation of lipopolysaccharide-binding protein(LBP), diabetic mice with high alloxan hyperglycaemia (higher than, or equal to 300 mg/100 mlof blood glucose) have been produced. It was shown that association of diabetes with abnormally high susceptibility to infections is partially caused by decreased level of LBP and that this negative phenomenon is linked to disturbances in lactoferrin action. Intravenous injection of bovine lactoferrin (bLF) may prevent against negative results of diabetes on immune system.

Keywords :
cattle / diabetes mellitus / immune system / lactoferrin lipopolysaccharide-binding protein / mice

Date Deposited : 08 Aug 2011 12:52

Last Modified : 08 Aug 2011 12:52

Official URL: http://www.ighz.edu.pl/

Volume 25, Number 4, - 2007

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