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.: Home > Animal Science Papers and Reports > 2006 > Volume 24 Number 1 > Tadeusz Malewski1, Alexei Sazanov2, Stanis³aw Kamiٌski3, Lech Zwierzchowski1, Zofia Szymaٌczak1

Co-expression of bovine statherin gene with casein gene CSN1S1

Tadeusz Malewski1, Alexei Sazanov2, Stanis³aw Kamiٌski3, Lech Zwierzchowski1, Zofia Szymaٌczak1
1 Department of Molecular Biology, Polish Academy of Sciences Institute of Genetics and Animal Breeding, Jastrzêbiec, 05-552 Wَlka Kosowska, Poland 2 Laboratory of Molecular Genome Organization, Institute of Farm Animal Genetics and Breeding, Russian Academy of Agricultural Sciences, Moskovskoye Shosse 55A, St. Petersburg-Pushkin 196601, Russia 3 Department of Animal Genetics, University of Warmia and Mazury in Olsztyn, Oczapowskiego 5, 10-719 Olsztyn, Poland
Abstract :

Regulatory sequences of the bovine casein genes are important both for establishing molecular
markers of milk production traits and creation of highly effective vectors for transgenesis. Casein
genes expression features suggest that the casein gene cluster can be regulated by locus control
region (LCR). In that cluster, apart from casein genes, localized are statherin (STATH), histatin
(HIS) and follicular dendritic cell-secreted protein (FDC-SP) genes. Sequence of bovine gene STATH is already known. Analyses of its expression in liver, spleen, kidney, longissimus dorsi muscle, pituitary gland, blood and mammary gland secretory tissue were performed showing that the gene was expressed exclusively in the mammary gland, exclusively during lactation.  Co-expression of gene STATH with gene CSN1S1 provides indirect evidence of the regulation by LCR.

Keywords :
cattle /casein genes / locus control region / milk / statherin gene

Date Deposited : 08 Aug 2011 12:57

Last Modified : 08 Aug 2011 12:57

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Volume 24, Number 1, - 2006

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