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.: Home > Animal Science Papers and Reports > 2005 > Volume 23 Number 4 > Artur Jَںwik, Anna Œliwa-Jَںwik, Adam Ko³¹taj

The effect of administration of high doses of selected antioxidants upon the activity of beta-glucuronidase (â-GL) in liver, kidney and blood plasma of mice

Artur Jَںwik, Anna Œliwa-Jَںwik, Adam Ko³¹taj
Polish Academy of Sciences Institute of Genetics and Animal Breeding, Jastrzêbiec, 05-552 Wَlka Kosowska, Poland
Abstract :

The activity of beta-glucuronidase (â-GL) was determined in lysosomal, microsomal and cytosolic
cellular subfractions of liver and kidney of mice and in mice blood plasma after intraperitoneal injections of reduced glutathione (GSH) and vitamins A, E and C. The â-GL activities were found to
depend on the antioxidant used, organ investigated and cellular subfraction analysed. The least â-GL reactivity was shown in blood plasma. It is concluded that the antioxidants injected can increase the activity of â-GL in cellular subfractions, particularly in microsomal fraction. The increase could be interpreted as physiological response of redox processes. The results presented allow to assume that the activity of â-GL can be used as an indicator of homeostasis disturbance.

Keywords :
antioxidants / beta-glucuronidase / cellular subfractions / glutathione / lysosomal enzymes / vitamins

Date Deposited : 10 Aug 2011 13:24

Last Modified : 10 Aug 2011 13:24

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Volume 23, Number 4, - 2005

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