UMM Logo

Universitas Muhammadiyah Malang


Free Download Journals Directory


Animal Science Papers and Reports

.: Home > Animal Science Papers and Reports > 2004 > Volume 22 Number 2 > Anna Œliwa-Jَںwik1, Artur Jَںwik1, Wojciech Fronczyk2, Andrzej Guszkiewicz1, Adam Ko³¹taj1

Effect of reduced glutathione (GSH) on activity of lysosomal system in subcellular fractions of mouse kidney

Anna Œliwa-Jَںwik1, Artur Jَںwik1, Wojciech Fronczyk2, Andrzej Guszkiewicz1, Adam Ko³¹taj1
1 Polish Academy of Sciences Institute of Genetics and Animal Breeding, Jastrzêbiec, 055-52 Wَlka Kosowska, Poland 2 Institute of Biology, Œwiêtokrzyska Academy, Œwiêtokrzyska 15, 25-406 Kielce, Poland
Abstract :

Investigated was the effect of intraperitoneal injections (twice daily for seven consecutive days) of
reduced glutathione (GSH) on activity of selected lysosomal hydrolases (alanine aminopeptidase,
leucine aminopeptidase, cathepsins D and L, acid phosphatase and N-acetyl-â-D-glucosaminidase) in lysosomal, microsomal and cytosol fractions of mouse kidney. Most notable effect of exogenous GSH on the activity of the enzymes considered was observed in lysosomal, while the least in microsomal fraction. After a series of GSH injections the activity of enzymes increased significantly mainly in lysosomal fraction. It is assumed that the increase in activity of lysosomal enzymes following the GSH injections results from a physiological response of renal cells to this antioxidant.

Keywords :
glutathione / hydrolases / kidney / lysosome / mouse

Date Deposited : 11 Aug 2011 10:26

Last Modified : 11 Aug 2011 10:26

Official URL: http://www.ighz.edu.pl/

Volume 22, Number 2, - 2004

Download:
Full Text Original
Abstract : pdf doc
Home | Peta Situs | Admissions | Student Research | E-Journal
Universitas Muhammadiyah Malang © 2011
Developed by Infokom UMM
Last Update : 13 December 2016 20:46Kumpulan file jurnal