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Animal Science Papers and Reports

.: Home > Animal Science Papers and Reports > 2004 > Volume 22 Number 4 > Krzysztof Flisikowski, Nina Strza³kowska, Krzysztof S³oniewski, Jَzef Krzy؟ewki, Lech Zwierzchowski

Association of a sequence nucleotide polymorphism in exon 16 of the STAT5A gene with milk production traits in Polish Black-and-White (Polish Friesian) cows

Krzysztof Flisikowski, Nina Strza³kowska, Krzysztof S³oniewski, Jَzef Krzy؟ewki, Lech Zwierzchowski
Polish Academy of Sciences Institute of Genetics and Animal Breeding, Jastrzêbiec, 05-552 Wَlka Kosowska, Poland
Abstract :

Signal transducer and activator of transcription 5 (STAT5) is a transcription factor that mediates
signals from prolactin and growth hormone, the main regulators of lactation and growth, respectively. Therefore, STAT5A gene is a candidate marker for quantitative traits in farm animals. Earlier, a nucleotide sequence polymorphism of the bovine STAT5A gene was found . the Tپ¨C transition at position 12743 in exon 16 coding for the transactivation domain SH2 of the STAT5A. This mutation has already been shown to modify the STAT5A DNA-binding properties. In the present paper, an association is reported between the STAT5A RFLP-MslI polymorphism and milk production traits in Polish Black-and-White (Polish Friesian) cattle. Cows of the STAT5A TC genotype produced daily significantly (P.0.05) more milk and FCM than TT homozygotes, with higher (P.0.05) content of lactose. Moreover, the daily yield of VCM, milk total solids, solids-non-fat, protein, and lactose was higher (P.0.01) in cows of TC than of TT genotype. No relationship was found beetwen the STAT5A RFLP-MslI genotype and protein and fat content of milk or the daily milk fat yield.

Keywords :
cattle / gene polymorphism / milk production traits / STAT5A gene

Date Deposited : 11 Aug 2011 13:03

Last Modified : 11 Aug 2011 13:03

Official URL: http://www.ighz.edu.pl/

Volume 22, Number 4, - 2004

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