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.: Home > Animal Science Papers and Reports > 2003 > Volume 21 Number 3 > Krzysztof Flisikowski, Jolanta Oprz¹dek, Edward Dymnicki, Lech Zwierzchowski

New polymorphism in the bovine STAT5A gene and its association with meat production traits in beef cattle*

Krzysztof Flisikowski, Jolanta Oprz¹dek, Edward Dymnicki, Lech Zwierzchowski
Polish Academy of Sciences Institute of Genetics and Animal Breeding, Jastrzêbiec, 05-552 Wَlka Kosowska, Poland
Abstract :

STAT5 is a group of transcription factors that mediate signals from prolactin and growth hormone.
Therefore, STAT5A gene is a candidate marker for quantitative traits in farm animals. In this study
the new nucleotide sequence polymorphism was found in the coding region of the bovine STAT5A
gene - substitution Cپ¨T at position 6853 within the exon 7. As this mutation creates new AvaI/DdeI
restriction site it could be easily detected with PCR-RFLP analysis. The RFLP-AvaI polymorphism was studied in cattle (n = 146) belonging to eight breeds, including two considered as Polish native. The overall frequencies of alleles C and T were 0.82 and 0.18, respectively. The genotype TT was found exclusively in both native breeds (Polish Red and White-Back). Moreover, for the first time an association was reported between STAT5A gene polymorphism and beef production traits in cattle (n = 71). In the animals of the CC genotype the live body weight at the age of 9 and 15 months, live weight gain (0-15 months), dressing percentage and four carcass traits were found more favourable than in CT animals. Individuals CC used less feed for maintenance and meat production.

Keywords :
carcass traits / cattle / growth rate / PCR/RFLP / polymorphism / STAT5A gene

Date Deposited : 12 Aug 2011 10:22

Last Modified : 01 Apr 2015 14:56

Official URL:

Volume 21, Number 3, - 2003

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