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International Journal Of Bilogical Sciences

.: Home > International Journal Of Bilogical Sciences > 2011 > Volume 7 Number 8 > Xiang Lin1,2,#, Yongyou Zhang1,*, Leyuan Liu1, Wallace L. McKeehan1, Yuemao Shen2, Siyang Song2,ƒx, and Fen Wang1

FRS2ƒر is Essential for the Fibroblast Growth Factor to Regulate the mTOR Pathway and Autophagy in Mouse Embryonic Fibroblasts

Xiang Lin1,2,#, Yongyou Zhang1,*, Leyuan Liu1, Wallace L. McKeehan1, Yuemao Shen2, Siyang Song2,ƒx, and Fen Wang1
1. Center for Cancer and Stem Cell Biology, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, TX; 2. The Key Laboratory of Education Ministry for Cell Biology and Tumor Cell Engineering; School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, P. R. China.
Abstract :

Although the fibroblast growth factor (FGF) signaling axis plays important roles in cell survival, proliferation, and differentiation, the molecular mechanism underlying how the FGF elicits these diverse regulatory signals is not well understood. By using the Frs2ƒر null mouse em-bryonic fibroblast (MEF) in conjunction with inhibitors to multiple signaling pathways, here we report that the FGF signaling axis activates mTOR via the FGF receptor substrate 2ƒر (FRS2ƒر)-mediated PI3K/Akt pathway, and suppresses autophagy activity in MEFs. In addition, the PI3K/Akt pathway regulated mTOR is crucial for the FGF signaling axis to suppress au-tophagy in MEFs. Since autophagy has been proposed to play important roles in cell survival, proliferation, and differentiation, the findings suggest a novel mechanism for the FGF signaling axis to transmit regulatory signals to downstream effectors.

Keywords :
FGF, autophagy, mouse embryonic fibroblast, receptor tyrosine kinase, cell signaling.

Date Deposited : 23 Sep 2011 13:37

Last Modified : 23 Sep 2011 13:37

Official URL: http://www.biolsci.org/

Volume 7, Number 8, - 2011

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