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International Journal Of Bilogical Sciences

.: Home > International Journal Of Bilogical Sciences > 2011 > Volume 7 Number 7 > Rou-Jun Peng1,2, Zhou-Feng Huang1,3,4, Yi-Lan Zhang1,3,4, Zhong-Yu Yuan1,2, Yi Xia1,2, Wen-Qi Jiang1,2, Yi-Xin Zeng1,4ƒx, Jiang Li1,3

Circulating and Tumor-Infiltrating Foxp3+ Regulatory T Cell Subset in Chinese Patients with Extranodal NK/T Cell Lymphoma

Rou-Jun Peng1,2, Zhou-Feng Huang1,3,4, Yi-Lan Zhang1,3,4, Zhong-Yu Yuan1,2, Yi Xia1,2, Wen-Qi Jiang1,2, Yi-Xin Zeng1,4ƒx, Jiang Li1,3
1. State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, China 2. Department of Medical Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, China 3. Department of Biotherapy Center, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, China 4. Department of Experimental Research, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, China
Abstract :

Foxp3+ regulatory T lymphocytes (Tregs) usually act as an immune suppressor and correlate with poorer survival in malignancies. This study aims to investigate the distribution and characterization of Foxp3+ subset in peripheral blood mononuclear cells (PBMCs) and tumor tissues from extranodal NK/T cell lymphoma (ENKTL). Our study showed the percentage of Foxp3+ subset from PBMC was significantly higher than that of healthy individuals (P<0.001). The Foxp3+ subset from PBMCs expressed CD45RO, CTLA4, GITR, CCR7, and had an IL-10highIFNƒ×+TGFƒز+IL-2lowIL-17low cytokine secreting phenotype. Interestingly, the existence of EBV antigen-specific CD8+Foxp3+ Tregs was discovered in ENKTL. Furthermore, the high density of Foxp3+ TILs was associated with improved progression-free survival (PFS) in ENKTL patients (P<0.05). Collectively, our study implicates that EBV antigens could induce antigen-specific CD8+Foxp3+ Tregs in ENKTL, and Foxp3+ TILs is an independent factor for PFS in ENKTL.

Keywords :
Foxp3+ regulatory T cells; Extranodal NK/T cell lymphoma; tumor infiltrating lym-phocytes; EBV

Date Deposited : 23 Sep 2011 14:03

Last Modified : 23 Sep 2011 14:03

Official URL: http://www.biolsci.org/

Volume 7, Number 7, - 2011

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