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International Journal Of Bilogical Sciences

.: Home > International Journal Of Bilogical Sciences > 2011 > Volume 7 Number 7 > Sandra Braun, Keren Bitton-Worms, Derek LeRoith

The Link between the Metabolic Syndrome and Cancer

Sandra Braun, Keren Bitton-Worms, Derek LeRoith
Diabetes and Metabolism Clinical Research Center of Excellence, Legacy Heritage Clinical Research Institute at Rambam (LHCRIR), Haifa, Israel.
Abstract :

Since the incidence of the metabolic syndrome is on the rise in the western world, its co-herence to cancer is becoming more apparent. In this review we discuss the different potential factors involved in the increase of cancer in the metabolic syndrome including obesity, dyslipidemia and Type 2 Diabetes Mellitus (T2DM) as well as inflammation and hypoxia. We especially focus on the insulin and IGF systems with their intracellular signaling cascades mediated by different receptor subtypes, and suggest that they may play major roles in this process. Understanding the mechanisms involved will be helpful in developing potential therapeutics

Keywords :
metabolic syndrome, cancer

Date Deposited : 23 Sep 2011 14:29

Last Modified : 23 Sep 2011 14:29

Official URL: http://www.biolsci.org/

Volume 7, Number 7, - 2011

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