UMM Logo

Universitas Muhammadiyah Malang


Free Download Journals Directory


Journal of Cancer

.: Home > Journal of Cancer > 2012 > Volume 3 Number 52 > Sidney W. Fu, M.D., Ph.D. Professor. Department of Medicin e, Division of Genomic Medicine, Department of Microbiology, Immunology and Tro pical Medicine , The George Washin gton University Medical Center, 2300 I Street, N.W. Room 443B , Washi ngton, DC 20037

Cell - free Circulating miRNA Biomarkers in Cancer

Sidney W. Fu, M.D., Ph.D. Professor. Department of Medicin e, Division of Genomic Medicine, Department of Microbiology, Immunology and Tro pical Medicine , The George Washin gton University Medical Center, 2300 I Street, N.W. Room 443B , Washi ngton, DC 20037
Email: sfu@gwu.edu Tel: 2029944767 Fax: 2029948924
Abstract :

Considerable attention and an enormous amount of resources have been dedicated to cancer biomarker discovery and validation. However, there are still a limited number of useful biomarkers available for clinical use. An ideal biomarker should be easily assayed with minimally invasive medical procedures but possess high sensitivity and specificity. Commonly used circulating biomarkers are proteins in serum, most of which require labor-intensive analysis hindered by low sensitivity in early tumor detection. Since the deregulation of microRNA (miRNA) is associated with cancer development and progression, profiling of circulating miRNAs has been used in a number of studies to identify novel minimally invasive miRNA biomarkers. In this review, we discuss the origin of the circulating cell-free miRNAs and their carriers in blood. We summarize the clinical use and function of potentially promising miRNA biomarkers in a variety of different cancers, along with their downstream target genes in tumor initiation and development. Additionally, we analyze some technical challenges in applying miRNA biomarkers to clinical practice.

Keywords :
serum, cancer, miRNA, biomarker

Date Deposited : 05 Jan 2015 15:10

Last Modified : 16 Jan 2015 11:02

Official URL: http://www.jcancer.org/

Volume 3, Number 52, - 2012

Download:
Full Text Original
Abstract : pdf doc