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International Journal of Poultry Science

.: Home > International Journal of Poultry Science > 2013 > Volume 12 Number 4 > W.X. Tian, N. Sun, G.B. Ning, D.J. Zhang, J. Feng, T.X. Lv, Y. Wang, H.M. Wang, X.H. Wang and F. Li

Effects of Gallid Herpesvirus 2 Marek's Disease Challenge Virus and Attenuated Vaccine Virus CVI988/Rispens on Immune Adhesion of Erythrocytes of Chickens

W.X. Tian, N. Sun, G.B. Ning, D.J. Zhang, J. Feng, T.X. Lv, Y. Wang, H.M. Wang, X.H. Wang and F. Li
College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu 030801, China
Abstract :

This study was designed to investigate the influence of Gallid herpesvirus 2 Marek's Disease challenge virus and different inoculated routes of attenuated vaccine virus CVI988/Rispens on immune adhesion of erythrocytes in chickens. One day old chicks were randomly divided into a control group (C), an experimental group challenged with Jing-1 challenge strain (V), a second and third experimental group individually injected intra-abdominally (IA) or subcutaneously (SC) with vaccine strain, CVI988/Rispens. The erythrocyte immune adhesion was evaluated with yeast rosette-forming tests of red blood cell complement receptor type 1 (RBC-CR1) and red blood cell immune complex (RBC-IC). It was found that chickens from group V had fewer erythrocytes. During this time, the rate of RBC-IC rosette formation was higher in group V except on days 3 and 20. While the rate of RBC-CR1 rosette formation was lower in group V except on the 26th day when the number of RBC-CR1 rosettes was extremely higher. The rate of RBC-CR1 rosette formation and RBCs count was higher in group IA than that of SC. The results suggest that challenge virus lead to immune suppression, a decline in the immune adhesion of RBCs followed by a rebound during the later stages of infection; effects on RBC immunity were increased after inoculate attenuated vaccines strains; IA vaccination route may enhance the immune adhesion of RBCs comparing with SC route; and an improvement in the RBC immunity adhesion during the later stages of infection may have resulted from a compensatory immune response to immune organ atrophy and the decrease of RBCs.

Keywords :
Gallid herpesviru s 2 Marek's disease challenge virus, attenuated vaccine virus CVI988/Rispens, erythrocyte, RBC-CR1 rosette, RBC-IC rosette

Date Deposited : 17 Mar 2015 11:43

Last Modified : 17 Mar 2015 11:43

Official URL: http://www.pjbs.org/ijps/back.htm

Volume 12, Number 4, - 2013 , ISSN 1682-8356

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