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International Journal of Poultry Science

.: Home > International Journal of Poultry Science > 2014 > Volume 13 Number 3 > Marcelo Lancellotti, Maria de Fatima da Silva Montassier, Filipe Santos Fernando, Ketherson Rodrigues Silva, Cintia Hiromi Okino, Igor Leonardo dos Santos, Romeu Moreira dos Santos, Mariana Monezi Borzi, Antonio Carlos Alessi, Gener T. Pereira and Helio Jose Montassier

Relationship Between Mucosal Antibodies and Immunity Against Avian Infectious Bronchitis Virus

Marcelo Lancellotti, Maria de Fatima da Silva Montassier, Filipe Santos Fernando, Ketherson Rodrigues Silva, Cintia Hiromi Okino, Igor Leonardo dos Santos, Romeu Moreira dos Santos, Mariana Monezi Borzi, Antonio Carlos Alessi, Gener T. Pereira and Helio Jose Montassier
Ketherson Rodrigues Silva , Cintia Hiromi Okino , Igor Leonardo dos Santos , Romeu Moreira dos Santos , 1 2 3 1 Mariana Monezi Borzi , Antônio Carlos Alessi , Gener T. Pereira and Helio Jose Montassier 1 4 1 1 Department of Veterinary Pathology-Laboratory of Veterinary Immunology and Virology, 1 School of Agricultural and Veterinary Sciences-Sao Paulo State University (FCAV-Unesp), Jaboticabal 14884-900, SP, Brazil Embrapa Swine and Poultry, Concórdia 89700-000, SC, Brazil 2 Zoetis Saúde Animal, Sao Paulo, SP, Brazil 3 Department of Veterinary Pathology-Laboratory of Veterinary Pathology, 4 School of Agricultural and Veterinary Sciences-Sao Paulo State University (FCAV-Unesp), Jaboticabal 14884-900, SP, Brazil
Abstract :

Immunity against avian infectious bronchitis virus (IBV) was assessed in specific pathogen free (SPF) chickens vaccinated at age of three weeks with H120 attenuated vaccine strain and, after three weeks, by measuring the virus-neutralizing and viral specific antibody isotypes in the mucosa (lachrymal secretion) and systemic (serum) compartments, followed by the evaluation of the protection to challenge with the M41 virulent strain of IBV. Lachrymal virus-neutralizing (VN) and IgG or IgA anti-IBV antibodies induced by H120-vaccination and detected at challenge showed significant correlation with the protection against IBV infection. No significant correlation was observed between lachrymal IgM anti-IBV antibodies, or between serum antibodies and protection to IBV infection. Therefore, the results of this study indicate that lachrymal antibodies, especially those expressing virus-neutralizing activity and from IgG and IgA isotypes, are effectively induced by immunization with IBV attenuated vaccine strain and are associated with the tracheal protection against IBV infection, suggesting that the levels of these lachrymal antibodies can be used for monitoring the protective immunity against IBV in vaccinated chickens.

Keywords :
Inf ectious bronchitis virus, lachrymal virus-neutralizing and IgG and IgA antibodies, trachea l humoral immunity, H120 attenuated vaccine

Date Deposited : 20 Mar 2015 14:52

Last Modified : 20 Mar 2015 14:52

Official URL: http://www.pjbs.org/ijps/ab2538.htm

Volume 13, Number 3, - 2014 , ISSN 1682-8356

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