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.: Home > Animal Science Papers and Reports > 2012 > Volume 30 Number 1 > Kamil Oleński 1, ** , Anna Cieślińska 1 , Tomasz Suchocki 2 , Joanna Szyda 2 , Stanisław Kamiński 1

Polymorphism in coding and regulatory sequences of beta-casein gene is associated with milk production traits in Holstein-Friesian cattle

Kamil Oleński 1, ** , Anna Cieślińska 1 , Tomasz Suchocki 2 , Joanna Szyda 2 , Stanisław Kamiński 1
Department of Animal Genetics, University of Warmia and Mazury in Olsztyn, 10-718 Olsztyn, Poland 2 Department of Animal Genetics, Wroclaw University of Environmental and Life Sciences, Kożuchowska 7, 51-631 Wrocław, Poland
Abstract :
Beta-casein gene
(CSN2)
is considered a marker of milk production traits in dairy cattle. Allele A2,
the most common in Holstein-Friesian breed, is beneficial for milk protein yield. However, within
CSN2
other mutations occur which could potentially be involved in shaping the variation of milk
production traits. In this study a new SNP (C/T) was found located within a regulatory sequence of
CSN2
(position -1578), called enhancer which is thought to play an important role in the amount of
the beta-casein mRNA produced. The aim of the study was to verify effects of both SNPs on milk
production traits in Polish Holstein-Friesian (HF) dairy cattle. Six-hundred-and-fifty bulls were
genotyped with two methods, PCR-ACRS (Amplification-Created Restriction Site, Mph1103 I) and
PCR-RFLP (EcoR I), for the A1/A2 polymorphism and the C/T SNP polymorphism (BCE129),
respectively. Although both SNPs are located close to each other, their allele frequencies were found
significantly different (0.33, 0.67, 0.89 and 0.11 for the A1, A2, C and T, respectively). A mixed linear
model was used for testing the association between these polymorphisms and deregressed breeding
values for production traits. The analysis revealed that the allele coding the A2 protein variant
increases breeding values for milk and milk protein yields while allele C of BCE129 increases the
milk fat yield.
Keywords :
beta-casein / breeding value /cattle /gene polymorphism / milk production traits

Date Deposited : 01 Apr 2015 15:06

Last Modified : 01 Apr 2015 15:06

Official URL: http://www.ighz.edu.pl/?p0=5&p1=34&o=7497

Volume 30, Number 1, - 2012

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