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Association between IGF1R / i16 / Taq I and IGF1 / SnaB I polymorphisms and milk production traits in Polish Holstein-Friesian cows

Małgorzata Szewczuk
Małgorzata Szewczuk 1, **, Sławomir Zych 2 , Ewa Czerniawska-Piątkowska
Abstract :
The insulin-like growth factor (IGF) signalling pathway plays a crucial role in the regulation of
growth and development of mammals. The strong mammary insulin-like growth factor receptor
type 1 (
IGF1R
) mRNA expression during lactation suggests a role for peripheral insulin-like growth
factor I (IGF-I) in maintenance of lactation. The aim of the study was to identify the frequencies of
alleles and genotypes of
IGF1/Sna
BI polymorphism and
two known polymorphisms within intron
16 of the
bIGF1R
gene (SNP ID rs41960582 and rs41960583)
as well as to determine associations
between these polymorphisms and milk production traits in Polish Holstein-Friesian cows.
The
frequency of
IGF1/Sna
BI allele A occurred similar to that of allele B (0.55 and 0.45, respectively). No
effect was found of
IGF1
genotype on milk production traits.
In the case of
IGF1R
polymorphisms
detected by
Taq
I digestion (frequency of allele
A
= 0.61 and 0.39 of allele
B
), no significant effects of
the
IGF1R/Taq
I polymorphism on the fat and protein yield and milk fat content was identified as well
as
no
association between
BB
genotype and milk yield (P≤0.05).
The high frequencies of all genotypes
for both polymorphisms enabled the analysis of association between genotype combinations and
milk traits. Cows with the
IGF1R
BB
/IGF1
AB
genotype combination (9% of the examined population)
yielded more milk, fat and protein compared to other combinations (P≤0.05).
Keywords :
cattle /insulin-like growth factor / milk production traits / SNP / QTL

Date Deposited : 01 Apr 2015 15:09

Last Modified : 01 Apr 2015 15:09

Official URL: http://www.ighz.edu.pl/?p0=5&p1=34&o=7497

Volume 30, Number 1, - 2012

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