UMM Logo

Universitas Muhammadiyah Malang

Free Download Journals Directory

Animal Science Papers and Reports

The chemokine receptor 1 gene polymorphism and its association with Somatic Cell Score and milk production traits in dairy cattle

Chun Lei Zhang
Institute of Cellular and Molecular Biology, Xuzhou Normal University, Xuzhou, Jiangsu, China
Abstract :
CXC chemokine receptors 1 (CXCR1) play a key role in inflammatory response and eventual
activation of the innate immunity. Mastitis is a big problem in dairy industry. In the presented study
the bovine CXCR1 gene was considered a candidate gene of anti-
defense in Chinese Holsteins.
Polymorphism of bovine
was investigated and its associations with Somatic Cell Scores
(SCS) and milk production traits (milk yield, milk fat and milk protein content) analysed. Six single
nucleotide polymorphisms (SNP) were identified within a 311 bp segment of the bovine
CXCR1 locus
at positions +570 (G>A), +642 (G>A), +735 (G>C), +816 (C>A), +819 (A>G) and +820 (G>A) relative
to the available mRNA sequence, of which
+820 G>A was revealed for the first time. The SNP
+735G>C resulted in the mutation of amino acid, but it showed no significant association
with the SCS, milk yield, milk fat and milk protein percentage of Chinese Holsteins (P>0.05). Fifteen
haplotypes were reconstructed by the six SNPs in the sample of Chinese Holstein population. The most
common haplotype was Haplo1 carrying alleles AAGCAG equal to 0.37, followed by 7 haplotypes
(from 2 to 7) with frequencies equal to 0.13, 0.11, 0.08, 0.08, 0.07, 0.07 and 0.06, respectively. Haplotype
analysis revealed no significant associations with SCS and other milk production traits.
Keywords :
CXCR1 gene / genetic resistance / haplotype / Holstein cattle / polymorphism / SNP

Date Deposited : 01 Apr 2015 15:11

Last Modified : 01 Apr 2015 15:11

Official URL:

Volume 30, Number 1, - 2012

Full Text Original
Abstract : pdf doc