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.: Home > Animal Science Papers and Reports > 2012 > Volume 30 Number 2 > Huiqin Zheng, Lanhui Li, Xianglong Li

Characterization and SNP identification of goat TYRP1 gene

Huiqin Zheng, Lanhui Li, Xianglong Li
College of Animal Science and Technology, Agricultural University of Hebei, Baoding 071000, Hebei, China
Abstract :
As a member of tyrosinase-related family, tyrosinase-related protein-1 (TYRP1) has been reported
to play an important role in melanin biosynthetic pathway in some species, but little is known
about its role in goat. In this study, almost complete goat
gene (17554 bp, HMO70243)
encompassing complete CDS was identified, the coding region amounting to 1614 bp, distributed in
7 exons (2-8), and intron 5 was found to possess GC-AG as its splice sites. Dozens of SNPs as well
as simple sequence repeat (SSR) motifs were detected in goat
gene, in which 4 SSR motifs
in intron 5 are combined in a tandem. Correlation analysis showed the allele A to be advantageous
compared to C at site
and allele C compared to T at
, implyimg that haplotype
AC is in favour of eumelanin biosynthesis, and haplotype CC is in favour of pheomelanin formation.
Marked deficiency of heterozygotes occurred in Nanjiang Yellow Goat Black strain and Nanjiang
Yellow Goat Fast Grow strain, indicating the high inbreeding in both strains.
Keywords :
oat colour / goat / SNP / TYRP1

Date Deposited : 01 Apr 2015 15:34

Last Modified : 01 Apr 2015 15:34

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Volume 30, Number 2, - 2012

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