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Induced pluripotent stem (iPS) cells in domestic animals − recent achievements − a review

Ewa Chronowska
Institute of Animal Science, Department of Biology of Reproduction, Pratelstvi 815, 10400, Prague, Czech Republic
Abstract :
Pluripotent cells show the unlimited self-renewal capacity and the potential to differentiate into
the cell lineages originating from three germ layers. To date real pluripotent stem cell
, able to
generate germ line chimeras, have been established in rodents. Large domestic animals, especially
pig, due to their considerable anatomical and physiological similarities with humans are thought
to be convenient model to test potential of pluripotent cells in cell replacement therapy before
their clinical use. However, creating pluripotent cells in domestic animals until now has met the
limitations due to lack of evidence for germ line contribution
Therefore they can not be considered
real pluripotent cells
but rather putative embryonic or embryonic-like stem
cells. Recently,
much attention has been drawn to the reprogramming technologies which enable redirection of
differentiated somatic cells to the pluripotent status. The aim of this review is to present the recent
achievements in generating of induced pluripotent stem (iPS) cells in domestic animals.
Keywords :
differentiation / iPS cells / pluripotency / proliferation / regenerative medicine / reprograming

Date Deposited : 02 Apr 2015 09:48

Last Modified : 02 Apr 2015 09:59

Official URL:

Volume 31, Number 2, - 2013

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