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Polymorphisms of Zygote arrest 1 gene and their effects on litter size in pigs

.J. Wu
association analysis / gene / litter size / pig / ZAR1/gene
Abstract :
Zygote arrest 1 (ZAR1) is oocyte-specific protein involved in the initiation of embryo development.
The objectives of this study were to identify novel mutations in
ZAR1
gene and investigate the
association between its genetic variants and litter size in Chinese local and European pigs. A novel
single nucleotide polymorphism (SNP) in exon 3 (g.2612T>C) and a 5 bp deletion/insertion in intron
3 (g.3838-3839insTGCAG) were found by sequencing and then their genotypes were identified in
218 sows of five breeds. The results of association analysis showed that the SNP g.2612T>C was
significantly related to litter size in Durocs (P<0.05), the sows with genotype
CC
genotype gave more
piglets than those of
TT
or/and
TC
genotypes. What’s more, the litter size in the Duroc breed was
also significantly dependent (P<0.05) on polymorphism in intron3 (g.3838-3839 sTGCAG). Sows
with
NN
genotype had more piglets per litter than those of
MM
or/and
MN
genotypes. A similar
relation (though not significant) was observed in remaining breeds tested. It is concluded that
ZAR1
gene might be a potential important candidate gene related to litter size in pigs.
Keywords :
association analysis / gene / litter size / pig / ZAR1 / gene

Date Deposited : 02 Apr 2015 09:55

Last Modified : 02 Apr 2015 09:55

Official URL: http://www.ighz.edu.pl/?p0=5&p1=34

Volume 31, Number 2, - 2013

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