UMM Logo

Universitas Muhammadiyah Malang


Free Download Journals Directory


Animal Bioresource in Japan

.: Home > Animal Bioresource in Japan > 2013 > Volume 62 Number 1 > Yan-Hua SANG, Yu-Xiang LIANG, Ling-Guang LIU, Rutledge G. ELLIS-BEHNKE, Wu-Tian WU, Kwok-Fai SO, Raymond Tak-Fai CHEUNG

A Rat Model of Intracerebral Hemorrhage Permitting Hematoma Aspiration plus Intralesional Injection

Yan-Hua SANG, Yu-Xiang LIANG, Ling-Guang LIU, Rutledge G. ELLIS-BEHNKE, Wu-Tian WU, Kwok-Fai SO, Raymond Tak-Fai CHEUNG
Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
Abstract :

A combination of hematoma aspiration and local delivery of chemicals may be more effective than either therapy in intracerebral hemorrhage (ICH). The aim of the present study was to develop a rat model of hematoma aspiration plus intralesional injection after ICH. ICH was induced in adult Sprague-Dawley rats by an intrastriatal injection of bacterial collagenase IV. Hematoma aspiration was performed 3.5 h after ICH onset. Following aspiration, normal saline was injected into the lesion cavity. Hematoma aspiration with or without subsequent saline injection significantly reduced the hematoma volume, lesion volume, and perihematomal neutrophil infiltration. Hematoma aspiration plus subsequent intralesional injection is simple, feasible, and safe. This ICH model can be used to assess the effectiveness of hematoma removal plus local delivery of chemicals.

Keywords :
animal model, hematoma aspiration, intracerebral hemorrhage, intralesional injection, rat

Date Deposited : 06 Apr 2015 11:21

Last Modified : 06 Apr 2015 11:21

Official URL: http://https://www.jstage.jst.go.jp/browse/expanim/62/1/_contents

Volume 62, Number 1, - 2013

Download:
Full Text Original
Abstract : pdf doc
Home | Peta Situs | Admissions | Student Research | E-Journal
Universitas Muhammadiyah Malang © 2011
Developed by Infokom UMM
Last Update : 13 December 2016 20:46Kumpulan file jurnal