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Animal Bioresource in Japan

.: Home > Animal Bioresource in Japan > 2013 > Volume 62 Number 3 > S. Anwar Jagessar, Michel Vierboom, Erwin L.A. Blezer, Jan Bauer, Bert A. ‘t Hart, Yolanda S. Kap

An Overview of Models, Methods, and Reagents Developed for Translational Autoimmunity Research in the Common Marmoset (Callithrix jacchus)

S. Anwar Jagessar, Michel Vierboom, Erwin L.A. Blezer, Jan Bauer, Bert A. ‘t Hart, Yolanda S. Kap
Department of Immunobiology, Biomedical Primate Research Centre, P.O. Box 3306, 2280 GH Rijswijk, The Netherlands
Abstract :

The common marmoset (Callithrix jacchus) is a small-bodied Neotropical primate and a useful preclinical animal model for translational research into autoimmune-mediated inflammatory diseases (AIMID), such as rheumatoid arthritis (RA) and multiple sclerosis (MS). The animal model for MS established in marmosets has proven their value for exploratory research into (etio) pathogenic mechanisms and for the evaluation of new therapies that cannot be tested in lower species because of their specificity for humans. Effective usage of the marmoset in preclinical immunological research has been hampered by the limited availability of blood for immunological studies and of reagents for profiling of cellular and humoral immune reactions. In this paper, we give a concise overview of the procedures and reagents that were developed over the years in our laboratory in marmoset models of the above-mentioned diseases.

Keywords :
experimental autoimmune encephalomyelitis, immunology, multiple sclerosis, nonhuman primate, rheumatoid arthritis

Date Deposited : 06 Apr 2015 11:43

Last Modified : 06 Apr 2015 11:43

Official URL: http://https://www.jstage.jst.go.jp/browse/expanim/62/1/_contents

Volume 62, Number 3, - 2013

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