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Animal Bioresource in Japan

.: Home > Animal Bioresource in Japan > 2013 > Volume 62 Number 3 > Zheyong Huang, Yunli Shen, Hongmin Zhu, Jianfeng Xu, Yanan Song, Xinying Hu, Zhang Shuning, Xiangdong Yang, Aijun Sun, Juying Qian, Junbo Ge

A New Coronary Retroinfusion Technique in theRat Infarct Model: Transjugular Cardiac Vein Catheterization

Zheyong Huang, Yunli Shen, Hongmin Zhu, Jianfeng Xu, Yanan Song, Xinying Hu, Zhang Shuning, Xiangdong Yang, Aijun Sun, Juying Qian, Junbo Ge
Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 180 Feng Lin Road, Shanghai 200032, P. R. China
Abstract :

Cell delivery via the retrograde coronary route boasts less vessel embolism, myocardial injury, and arrhythmogenicity when compared with those via antegrade coronary administration or myocardial injection. However, conventional insertion into the coronary sinus and consequent bleeding complication prevent its application in small animals. To overcome the complication of bleeding, we described a modified coronary retroinfusion technique via the jugular vein route in rats with myocardial infarction (MI). A flexible wire with a bent end was inserted into the left internal jugular vein and advanced slowly along the left superior vena cava. Under direct vision, the wire was run into the left cardiac vein by rotating the wire and changing the position of its tip. A fine tube was then advanced along the wire to the left cardiac vein. This modified technique showed less lethal hemorrhage than the conventional technique. Retroinfusion via transjugular catheter enabled efficient fluid or cell dissemination to the majority areas of the free wall of the left ventricle, covering the infarcted anterior wall. In conclusion, transjugular cardiac vein catheterization may make retrocoronary infusion a more safe and practical route for delivering cell, drug, and gene therapy into the infarcted myocardium of rats.

Keywords :
animal model, cardiac vein, cell transplantation, myocardial infarction, rats, transjugular

Date Deposited : 06 Apr 2015 11:49

Last Modified : 06 Apr 2015 11:49

Official URL: http://https://www.jstage.jst.go.jp/browse/expanim/62/1/_contents

Volume 62, Number 3, - 2013

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