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Animal Bioresource in Japan

.: Home > Animal Bioresource in Japan > 2013 > Volume 62 Number 3 > Jung-Hoon Kim, Eun-Hye Shin, Hak-Yong Lee, Bong-Gun Lee, Sang-Hoon Park, Dae-In Moon, Gyo-Chang Goo, Dae-Young Kwon, Hye-Jeong Yang, Ok-Jin Kim, Hong-Geun Oh

Immunostimulating Effects of Extract of Acanthopanax sessiliflorus

Jung-Hoon Kim, Eun-Hye Shin, Hak-Yong Lee, Bong-Gun Lee, Sang-Hoon Park, Dae-In Moon, Gyo-Chang Goo, Dae-Young Kwon, Hye-Jeong Yang, Ok-Jin Kim, Hong-Geun Oh
Huvet Co., Ltd., #203 Wonkwang University Business Incubator Center, 344-2 Shinyoung-dong, Iksan, Jeonbuk 570-749 Korea
Abstract :

As malfunction/absence of immune cells causes a variety of immunosuppressive disorders and chemical synthetic drugs for curing these diseases have many adverse effects, vigorous studies are being conducted. The Acanthopanax family has been used as traditional medicines for gastric ulcer, diabetes, etc. and culinary materials in East-South Asia. In this study, the immunostimulating properties of A. sessiliflorus were evaluated. A. sessiliflorus increased not only the splenocyte number but also immune-related cytokines such as TNF-α. However, it could not upregulate the expressions of IFN-γ and IL-2. A. sessiliflorus increased the swimming time, and comparison of organ weights relative to body weights for immune-related organs such as the spleen and thymus after a forced swim test showed that it could recover the spleen and thymus weights. It also increased the expression of TNF-α and slightly increased the concentration of IFN-γ but not IL-2. From the results, we concluded that as A. sessiliflorus has not only a host defense effect but also a stress-ameliorating property, further study it will be a promising material of immunostimulating material.

Keywords :
Acanthopanax sessiliflorus , IFN-γ, immunostimulating, rat, TNF-α

Date Deposited : 06 Apr 2015 12:01

Last Modified : 06 Apr 2015 12:01

Official URL: http://https://www.jstage.jst.go.jp/browse/expanim/62/1/_contents

Volume 62, Number 3, - 2013

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