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Animal Bioresource in Japan

.: Home > Animal Bioresource in Japan > 2014 > Volume 63 Number 2 > Yoshiaki Katsuda, Takeshi Ohta, Katsuhiro Miyajima, Yusuke Kemmochi, Tomohiko Sasase, Bin Tong, Masami Shinohara, Takahisa Yamada

Diabetic Complications in Obese Type 2 Diabetic Rat Models

Yoshiaki Katsuda, Takeshi Ohta, Katsuhiro Miyajima, Yusuke Kemmochi, Tomohiko Sasase, Bin Tong, Masami Shinohara, Takahisa Yamada
Japan Tobacco Inc., Central Pharmaceutical Research Institute, 1–1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan
Abstract :

We overviewed the pathophysiological features of diabetes and its complications in obese type 2 diabetic rat models: Otsuka Long-Evans Tokushima fatty (OLETF) rat, Wistar fatty rat, Zucker diabetic fatty (ZDF) rat and Spontaneously diabetic Torii (SDT) fatty rat. Pancreatic changes with progression of diabetes were classified into early changes, such as islet hypertrophy and degranulation of β cells, and degenerative changes, such as islet atrophy and fibrosis of islet with infiltration of inflammatory cells. Renal lesions in tubuli and glomeruli were observed, and nodular lesions in glomeruli were notable changes in OLETF and SDT fatty rats. Among retinal changes, folding and thickening were interesting findings in SDT fatty rats. A decrease of motor nerve conduction velocity with progression of diabetes was presented in obese diabetic rats. Other diabetic complications, osteoporosis and sexual dysfunction, were also observed. Observation of bone metabolic abnormalities, including decrease of osteogenesis and bone mineral density, and sexual dysfunction, including hypotestosteronemia and erectile dysfunction, in obese type 2 diabetic rats have been reported.

Keywords :
animal model, diabetes, diabetic complication, obese, SDT fatty rat

Date Deposited : 07 Apr 2015 09:52

Last Modified : 07 Apr 2015 09:52

Official URL: http://https://www.jstage.jst.go.jp/browse/expanim/62/1/_contents

Volume 63, Number 2, - 2014

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