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Animal Bioresource in Japan

.: Home > Animal Bioresource in Japan > 2014 > Volume 63 Number 3 > Juan P. Damián, Victoria Acosta, Maira Da Cuña, Isara Ramírez, Natalia Oddone, Ana Zambrana, Verónica Bervejillo, Juan C. Benech

Effect of Resveratrol on Behavioral Performanceof Streptozotocin-induced Diabetic Mice inAnxiety Tests

Juan P. Damián, Victoria Acosta, Maira Da Cuña, Isara Ramírez, Natalia Oddone, Ana Zambrana, Verónica Bervejillo, Juan C. Benech
1)Laboratorio de Señalización Celular y Nanobiología, Instituto de Investigaciones Biológicas Clemente Estable (IIBCE), Av. Italia 3318, 11600 Montevideo, Uruguay 2)Departamento de Biología Molecular y Celular, Facultad de Veterinaria, Universidad de la República, Lasplaces 1550, 11600 Montevideo, Uruguay
Abstract :

The aim of this study was to evaluate with anxiety tests the effect of resveratrol (RSV) on streptozotocin (STZ)-induced diabetic mouse behavioral performance at the second and fourth week of treatment. Confirmed diabetic mice (>250 mg/dl of glucose in blood after STZ injection) were treated with RSV (RDM, n=12) or control treated (DM, n=12) for 4 weeks. DM and RDM were tested in the Open Field Test (OFT) and Elevated Plus Maze (EPM). In the second week of RSV treatment, a higher grooming frequency (P<0.05) and a lower defecation and rearing frequency (P<0.05) were detected in the OFT in the RDM group compared with the DM. There was a higher grooming frequency (P<0.05) and higher percentage of entries in open arms (P<0.05) in the RDM group than in the DM group in the EPM. However, in the fourth week of RSV treatment, the only effect observed was a higher grooming frequency in the RDM group than in the DM group (P<0.05) in the EPM. In conclusion, RSV treatment in diabetic mice provoked anxiolytic-like effects in both tests (OFT and EPM), and these effects were observed in a short time window (2 weeks). It is suggested that RSV may help diabetic animals to adapt to new stressing and anxiety situations and thus to improve their welfare.

Keywords :
diabetes, flavonoid, mouse, resveratrol, stress

Date Deposited : 07 Apr 2015 10:20

Last Modified : 07 Apr 2015 10:20

Official URL: http://https://www.jstage.jst.go.jp/browse/expanim/62/1/_contents

Volume 63, Number 3, - 2014

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