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Animal Bioresource in Japan

Mechanism of Fertilization: A Modern View

Masaru OKABE
Center for Genetic Analysis for Biological Responses, Research Institute for Microbial Diseases, Osaka University, Yamadaoka 3-1, Suita, Osaka 565-0871, Japan
Abstract :

Despite numerous studies on mammalian fertilization, the mechanisms of fertilization—including the timing of acrosome reaction—remain largely unknown; more accurately described, the classical theory built upon years of layered experimental data is being challenged by recent conflicting evidence provided by gene-manipulated animals. Although in vitro fertilization remains our central research tool, the classical theory’s decline reminds us of the importance of in vivo observations. Here, I describe the essential roles of gene-manipulated animals in elucidating the mechanism of fertilization and the pitfalls of in vitro fertilization studies trapping many researchers.

Keywords :
acrosome reaction, fertilization, gene-manipulated animals, live imaging, sperm-egg fusion

Date Deposited : 07 Apr 2015 10:35

Last Modified : 07 Apr 2015 10:35

Official URL: http://

Volume 63, Number 4, - 2014

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