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Animal Bioresource in Japan

.: Home > Animal Bioresource in Japan > 2015 > Volume 64 Number 1 > Saeed SAMARGHANDIAN, Mohsen AZIMI-NEZHAD, Fariborz SAMINI

Preventive effect of safranal against oxidative damage in aged male rat brain

Saeed SAMARGHANDIAN, Mohsen AZIMI-NEZHAD, Fariborz SAMINI
1)Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran 2)Department of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran 3)Department of Neurosurgery, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract :

An imbalance between production of reactive oxygen species (ROS) and its elimination by antioxidant defense system in the body has been implicated for causes of aging and neurodegenerative diseases. This study was design to assess the changes in activities of antioxidant enzymes (superoxide dismutase (SOD), glutathione-S-transferase (GST), catalase), lipid peroxidation and reduced glutathione (GSH) levels in the brain of 2, 10 and 20 month old rats, and to determine the effect of safranal on the status of selected oxidative stress indices in the 10 and 20 month old rats. The aged rats (10 and 20 months) were given intraperitoneal injections of safranal (0.5 mg/kg day) daily for one month. The results of this study demonstrated that aging caused significant increase in the level of lipid peroxidation as well decrease in the GSH level and activities of SOD and GST in the brain of aging rats. The results of this study showed that safranal ameliorated the increased lipid peroxidation level as well as decreased GSH content of the brain of 10 and 20 month old rats. In addition, safranal treatment to the 20 month old rats, which restored the SOD and GST activities. In conclusion, safranal can be effective to protect susceptible aged brain from oxidative damage by increasing antioxidant defenses.

Keywords :
aged, brain, oxidative damage, safranal

Date Deposited : 08 Apr 2015 09:43

Last Modified : 08 Apr 2015 09:43

Official URL: http://https://www.jstage.jst.go.jp/browse/expanim/62/1/_contents

Volume 64, Number 1, - 2015

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