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International Journal Of Bilogical Sciences

.: Home > International Journal Of Bilogical Sciences > 2011 > Volume 7 Number 9 > César A. Terrazas3*, Fausto Sánchez-Muñoz1*, Ana M. Mejía-Domínguez2, Luis M. Amezcua-Guerra1, Luis I. Terrazas3, Rafael Bojalil1,4, Lorena Gómez-García1✉

Cestode Antigens Induce a Tolerogenic-Like Phenotype and Inhibit LPS Inflammatory Responses in Human Dendritic Cells

César A. Terrazas3*, Fausto Sánchez-Muñoz1*, Ana M. Mejía-Domínguez2, Luis M. Amezcua-Guerra1, Luis I. Terrazas3, Rafael Bojalil1,4, Lorena Gómez-García1✉
1. Department of Immunology, Instituto Nacional de Cardiología Ignacio Chávez, México City, México 2. Blood Bank, Instituto Nacional de Cardiología Ignacio Chávez, México City, México 3. Biomedicine Unit, Facultad de Estudios Superiores Iztacala, UNAM, México City, México 4. Department of Health Care, Universidad Autónoma Metropolitana Xochimilco, México City, México
Abstract :

Pathogens have developed strategies to modify Dendritic Cells (DCs) phenotypes and impair their functions in order to create a safer environment for their survival. DCs responses to helminths and their derivatives vary among different studies. Here we show that excretory/secretory products of the cestode Taenia crassiceps (TcES) do not induce the maturation of human DCs judged by a lack of increment in the expression of CD83, HLA-DR, CD80 and CD86 molecules but enhanced the production of IL-10 and positively modulated the expression of the C-type lectin receptor MGL and negatively modulated the expression of DC-SIGN. Additionally, these antigens were capable of down-modulating the inflammatory response induced by LPS in these cells by reducing the expression of the maturation markers and the production of the inflammatory cytokines IL-1β, TNF, IL-12 and IL-6. The effects of TcES upon the DCs responses to LPS were stronger if cells were exposed during their differentiation to the helminth antigens. All together, these findings suggest the ability of TcES to induce the differentiation of human DCs into a tolerogenic-like phenotype and to inhibit the effects of inflammatory stimuli.

Keywords :
Dendritic cells, tolerogenic phenotype, Taenia crassiceps.

Date Deposited : 08 Apr 2015 13:14

Last Modified : 08 Apr 2015 13:14

Official URL: http://www.ijbs.com/ms/archive

Volume 7, Number 9, - 2011 , ISSN 1545-1003

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