International Journal Of Bilogical Sciences
.: Home > International Journal Of Bilogical Sciences > 2012 > Volume 8 Number 2 > Dechun Feng1#, Ogyi Park1#, Svetlana Radaeva2, Hua Wang1, Shi Yin1, Xiaoni Kong1, Mingquan Zheng3, Sam Zakhari2, Jay K. Kolls3, Bin Gao1 ✉
Interleukin-22 Ameliorates Cerulein-Induced Pancreatitis in Mice by Inhibiting the Autophagic Pathway
Dechun Feng1#, Ogyi Park1#, Svetlana Radaeva2, Hua Wang1, Shi Yin1, Xiaoni Kong1, Mingquan Zheng3, Sam Zakhari2, Jay K. Kolls3, Bin Gao1 ✉
1. Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD 20892, USA; 2. Division of Metabolism and Health Effects, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD 20892, USA; 3. Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.
Pancreatitis occurs when digestive enzymes are activated in the pancreas. Severe pancreatitis has a 10-30% mortality rate. No specific treatments for pancreatitis exist now. Here, we discovered that interleukin-22 (IL-22) may have therapeutic potential in treating acute and chronic pancreatitis. Wild-type and IL-22 knockout mice were equally susceptible to cerulein-induced acute and chronic pancreatitis, whereas liver-specific IL-22 transgenic mice were completely resistant to cerulein-induced elevation of serum digestive enzymes, pancreatic necrosis and apoptosis, and inflammatory cell infiltration. Treatment of wild-type mice with recombinant IL-22 or adenovirus IL-22 markedly attenuated the severity of cerulein-induced acute and chronic pancreatitis. Mechanistically, we show that the protective effect of IL-22 on pancreatitis was mediated via the induction of Bcl-2 and Bcl-XL, which bind to Beclin-1 and subsequently inhibit autophagosome formation to ameliorate pancreatitis. In conclusion, IL-22 ameliorates cerulein-induced pancreatitis by inhibiting the autophagic pathway. IL-22 could be a promising therapeutic drug to treat pancreatitis.
IL-22, pancreatitis, autophagy, Bcl-2, Beclin-1.
Date Deposited : 09 Apr 2015 10:32
Official URL: http://www.ijbs.com/ms/archive
Last Modified : 09 Apr 2015 10:32
Volume 8, Number 2, - 2012 , ISSN 1545-1003
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