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International Journal Of Bilogical Sciences

.: Home > International Journal Of Bilogical Sciences > 2012 > Volume 8 Number 2 > Feng Zhi1,2, Guangming Gong1, Yan Xu1, Yan Zhu1, Die Hu1, Yilin Yang2,✉, Yiqiao Hu1,✉

Activated β-catenin Forces N2A Cell-derived Neurons Back to Tumor-like Neuroblasts and Positively Correlates with a Risk for Human Neuroblastoma

Feng Zhi1,2, Guangming Gong1, Yan Xu1, Yan Zhu1, Die Hu1, Yilin Yang2,✉, Yiqiao Hu1,✉
1. ­­­­State Key Laboratories of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China 2. Third Affiliated Hospital of Soochow University, Changzhou, China
Abstract :

Neuroblastoma is an embryonic malignancy arising from neuroblasts. The mechanisms that regulate the origination of neuroblastoma are still not very clear. In this study, we revealed that 6-bromoindirubin 3'-oxime (BIO), a specific GSK-3β inhibitor, promoted N2A cells-derived neurons to become tumor-like neuroblasts. Moreover, constitutively activated β-catenin (S33Y) also promoted this process, whereas, silencing endogenous expression of β-catenin abolished BIO-induced effects. These results implicated the potential relationship between the Wnt/β-catenin signaling and neuroblastoma formation. Indeed, we found that the amount of β-catenin in nucleus, which indicated the activation of Wnt/β-catnin signaling, was accumulated in human neuroblastoma specimens and positively correlated with clinical risk of neuroblastoma. These results give us a new sight into the neuroblastoma initiation and progression, and provide a potential drug target for neuroblastoma treatment.

Keywords :
euroblastoma, GSK-3β, β-catenin, neuroblasts

Date Deposited : 09 Apr 2015 10:37

Last Modified : 09 Apr 2015 10:37

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Volume 8, Number 2, - 2012 , ISSN 1545-1003

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