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International Journal Of Bilogical Sciences

.: Home > International Journal Of Bilogical Sciences > 2012 > Volume 8 Number 5 > Rui-Xing Yin1✉, Dong-Feng Wu1, Jin-Zhen Wu1, Xiao-Li Cao1, Lynn Htet Htet Aung1, Lin Miao1, Xing-Jiang Long1, Wan-Ying Liu2, Lin Zhang3, Meng Li4

Interactions of Several Lipid-Related Gene Polymorphisms and Cigarette Smoking on Blood Pressure Levels

Rui-Xing Yin1✉, Dong-Feng Wu1, Jin-Zhen Wu1, Xiao-Li Cao1, Lynn Htet Htet Aung1, Lin Miao1, Xing-Jiang Long1, Wan-Ying Liu2, Lin Zhang3, Meng Li4
1. Department of Cardiology, Institute of Cardiovascular Diseases, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, People's Republic of China; 2. Department of Cardiology, the Third Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, People's Republic of China; 3. Department of Cardiology, the People's Hospital of Guilin, Guilin, Guangxi, People's Republic of China; 4. Department of Internal Medicine, Worker's Hospital of Guangxi Liuzhou Iron and Steel (Group) Company, Liuzhou, Guangxi, People's Republic of China.
Abstract :

The interactions of single nucleotide polymorphisms (SNPs) and cigarette smoking on blood pressure levels are limited. The present study was undertaken to detect nine lipid-related SNPs and their interactions with cigarette smoking on blood pressure levels. Genotyping of ATP-binding cassette transporter A1 (ABCA-1) V825I, acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) rs1044925, low density lipoprotein receptor (LDL-R) AvaⅡ, hepatic lipase gene (LIPC) -250G>A, endothelial lipase gene (LIPG) 584C>T, methylenetetrahydrofolate reductase (MTHFR) 677C>T, proprotein convertase subtilisin-like kexin type 9 (PCSK9) E670G, peroxisome proliferator-activated receptor delta (PPARD) +294T>C, and Scavenger receptor class B type 1 (SCARB1) rs5888 was performed in 935 nonsmokers and 845 smokers. The interactions were detected by factorial regression analysis. The frequencies of genotypes (ACAT-1 and LIPG), alleles (ABCA-1), and both genotypes and alleles (LDL-R, LIPC, PPARD and SCARB1) were different between nonsmokers and smokers (P < 0.05-0.001). The levels of pulse pressure (PP, ABCA-1), and systolic, diastolic blood pressure (SBP, DBP) and PP (LIPC) in nonsmokers were different among the genotypes (P < 0.01-0.001). The levels of SBP (ABCA-1, ACAT-1, LIPG and PCSK9), DBP (ACAT-1, LDL-R, LIPC, PCSK9 and PPARD), and PP (LIPC, LIPG, MTHFR and PCSK9) in smokers were different among the genotypes (P < 0.01-0.001). The SNPs of ABCA-1, ACAT-1 and PCSK9; ACAT-1, LDL-R, MTHFR and PCSK9; and ABCA-1, LIPC, PCSK9 and PPARD were shown interactions with cigarette smoking to influence SBP, DBP and PP levels (P < 0.05-0.001); respectively. The differences in blood pressure levels between the nonsmokers and smokers might partly result from different interactions of several SNPs and cigarette smoking.

Keywords :
blood pressure, hypertension, genetic polymorphism, cigarette smoking, interaction.

Date Deposited : 09 Apr 2015 13:28

Last Modified : 09 Apr 2015 13:28

Official URL: http://www.ijbs.com/ms/archive

Volume 8, Number 5, - 2012 , ISSN 1545-1003

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