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International Journal Of Bilogical Sciences

.: Home > International Journal Of Bilogical Sciences > 2012 > Volume 8 Number 6 > Guangwen Long*, Feng Wang*, Quanlu Duan, Fuqiong Chen, Shenglan Yang, Wei Gong, Yan Wang, Chen Chen✉, Dao Wen Wang✉

Human Circulating MicroRNA-1 and MicroRNA-126 as Potential Novel Indicators for Acute Myocardial Infarction

Guangwen Long*, Feng Wang*, Quanlu Duan, Fuqiong Chen, Shenglan Yang, Wei Gong, Yan Wang, Chen Chen✉, Dao Wen Wang✉
Department of Internal Medicine and the Institute of Hypertension, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Abstract :

Circulating miRNAs have been shown as promising biomarkers for various pathologic conditions. The aim of this study was to clarify that circulating miR-1 and miR-126 in human plasma might be useful as biomarkers in acute myocardial infarction (AMI). In our study, after pre-test, two candidate miRNAs were detected by using real-time RT-PCR. Cardiac troponin I (cTnI) concentrations were measured by ELISA assay in plasma from patients with AMI (n=17) and healthy subjects (n=25), simultaneously. Increased miR-1 and decreased miR-126 in plasma from patients with AMI after the onset of symptoms compared with healthy subjects were found. A remarkable finding in this study is that miR-1, miR-126 and cTnI expression levels exhibited the same trend. Our results suggest that the plasma concentrations of miR-1 and miR-126 may be useful indicators for AMI.

Keywords :
circulating miRNA, biomarker, AMI.

Date Deposited : 09 Apr 2015 13:39

Last Modified : 09 Apr 2015 13:39

Official URL: http://www.ijbs.com/ms/archive

Volume 8, Number 6, - 2012 , ISSN 1545-1003

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