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International Journal Of Bilogical Sciences

.: Home > International Journal Of Bilogical Sciences > 2012 > Volume 8 Number 6 > Man-Bo Cai1,2*, Hui-Qiong Han1*, Jin-Xin Bei1*, Chao-Chun Liu3, Jin-Ju Lei1, Qian Cui1, Qi-Sheng Feng1, Hai-Yun Wang4, Jia-Xing Zhang4, Yi Liang1, Li-Zhen Chen1, Tie-Bang Kang1, Jian-Yong Shao4, Yi-Xin Zeng1✉

Expression of Human Leukocyte Antigen G is associated with Prognosis in Nasopharyngeal Carcinoma

Man-Bo Cai1,2*, Hui-Qiong Han1*, Jin-Xin Bei1*, Chao-Chun Liu3, Jin-Ju Lei1, Qian Cui1, Qi-Sheng Feng1, Hai-Yun Wang4, Jia-Xing Zhang4, Yi Liang1, Li-Zhen Chen1, Tie-Bang Kang1, Jian-Yong Shao4, Yi-Xin Zeng1✉
1. State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, Guangzhou, China; 2. Cancer Research Institute, University of South China, Hengyang, China; 3. Wadsworth Center, New York State Department of Health, Albany, New York, USA; 4. Department of Molecular Diagnostics, Cancer Center, Sun Yat-Sen University, Guangzhou, China.
Abstract :

Human leukocyte antigen G (HLA-G) has multiple immune regulatory functions including the induction of immune tolerance in malignancies. The roles of HLA-G have not been investigated in nasopharyngeal carcinoma (NPC). This study is aimed to evaluate the role of HLA-G as prognostic factor for NPC patients as well as its role in the immune regulation. Western assays showed high HLA-G expression in NPC cell lines, but low in the immortalized nasopharyngeal epithelial cell line NP69. HLA-G protein was further detected in 79.2% of 552 NPC specimens with immunohistochemistry (IHC), but not in normal nasopharyngeal epithelium tissue. Moreover, high expression of HLA-G predicted poor survival of NPC patients and positively correlated with tumor N classification and recurrence or metastasis. Multivariate analysis indicated that HLA-G was an independent and unfavorable prognostic factor. Furthermore, the presence of CD68+macrophages and IL-10 were also examined, which are two prognostic markers of NPC and important factors for regulating immune surveillance. The correlations of HLA-G with these two immune factors were revealed in NPC tissues. Taken together, our results suggest that HLA-G is an independent biomarker for NPC prognosis, and HLA-G might contribute to NPC progression, which might jointly regulate immune surveillance in NPC together with macrophages and IL-10.

Keywords :
Nasopharyngeal carcinoma, HLA-G, Prognosis, IL-10, macrophage

Date Deposited : 09 Apr 2015 13:49

Last Modified : 09 Apr 2015 13:49

Official URL: http://www.ijbs.com/ms/archive

Volume 8, Number 6, - 2012 , ISSN 1545-1003

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